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  • Magnolia Bark Extract

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  • Magnolia Bark Extract

  • Latin Name:Cortex Magnoliae Officinalis
  • Ative Ingredients:Magnolol, Honokiol, Tetrahhydromagnolol, Isomagnolol and so on.
  • Major Components:Magnolol
  • Specifications:Honokiol and Magnolol 2%~98% HPLC
  • Assay Method:HPLC
  • Magnolia Bark Extract
  • Pharmacology:Straight powder
    Honokiol 10-98% , Magnolol 10-98%
    Honokiol and Magnolol 2%~98% HPLC
    Appearance: Dark brown to White powder
    Active Ingredient: Magnolol
    CAS No.: 528-43-8
    Molecular Formula: C18H18O2
    Molecular Mass: 266.33
    Active Ingredient: Honokiol
    CAS No.: 35354-74-6
    Molecular Formula: C18H18O2
    Molecular Mass: 266.33

    Anti-tumorigenic activities :
    Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma andcolon cancer cell lines. Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiolregulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), MCL1, and cyclooxygenase 2 (COX-2), all significant pro-angiogenic and survival factors.

    Neurotrophic activity :
    Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons.
    Additionally, honokiolincreases free cytoplasmic Ca2+ in rat cortical neurons.
    Honokiol is a weak cannabinoid CB2 receptor ligand but the naturally occurring derivative 4-Omethylhonokiol was shown to be a potent and selective cannabinoid CB2 receptor inverse agonist and to possess antiosteoclastic effects.

    Anti-thrombotic activity :
    1) Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotein injury.
    2) Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.

  • Tag: Ratio Herbal Extract manufacturer, Magnolia, Magnolia Bark, Bark Extract, Magnolia Extract, Ratio Magnolia, Ratio Herbal Magnolia Bark, Herbal Extract Magnolia Bark Extract, Ratio Extract Magnolia Extract

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